Search results for "Unspecific monooxygenase"
showing 2 items of 2 documents
Confirmation of in situ exposure of fish to secondary treated bleached-kraft mill effluent using a laboratory simulation
1998
To corroborate the responses in whitefish (Coregonus Iavaretus L.) exposed to elemental chlorine free (ECF) bleached-kraft pulp mill effluent (BKME) in situ, a 30-d laboratory exposure was carried out at concentrations simulating the field conditions. The flow-through exposures were conducted at four secondary (activated sludge) treated effluent (STE) concentrations: 1.3, 2.3, 3.5, and 7%. To evaluate the role of the secondary treatment, fish were also exposed to one concentration (3.5%) of pretreated effluent (PTE) from the mill. Compared to the control, whitefish liver 7-ethoxyresorufin-O-deethylase (EROD) activity was twofold in fish exposed to 3.5% STE, which was similar to monooxygenas…
SULFUR ANALOGUES OF POLYCHLORINATED DIBENZO-p-DIOXINS, DIBENZOFURANS AND DIPHENYL ETHERS AS INDUCERS OF CYP1A1 IN MOUSE HEPATOMA CELL CULTURE AND STR…
1994
Three sulfur-containing compounds, 2,3,7,8-tetrachlorothianthrene (TCTA), 2,3,7,8-tetrachlorodibenzothiophene (TCDT), and 3,3[prime],4,4[prime]-tetrachlorodiphenyl sulfide (TCDPS), were analyzed for their CYP1A1-inducing potencies--measured as aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin O-deethylase (EROD) activities--in mouse hepatoma cell culture Hepa-1. Marked differences in the induction potencies were observed among the three compounds studied and between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its sulfur analogue. The estimated EC50 values for TCDD, TCTA, and TCDT were about 8 pM, 700 pM, and 7.5 nM, respectively. TCDPS did not elicit any AHH/EROD induction. Compar…